RT journal article
T1 Endometrial polyps in obese asymptomatic pre and postmenopausal patients with breast cancer: is screening necessary?
T2 Pólipos endometriales en pacientes obesas asintomáticas pre y posmenopáusicas con cáncer de mama: ¿es necesario el cribado?
A1 Lubián López, Daniel María
A1 Orihuela López, Francisco
A1 García-Berbel Molina, Lucía
A1 Boza Novo, Patricia
A1 Pozuelo Solís, Estrella
A1 Menor Almagro, David
A1 Comino Delgado, Rafael
A2 Materno-Infantil y Radiología
K1 Breast cancer
K1 Endometrial polyp
K1 Obesity
K1 Hysteroscopy
K1 Menopausal status
K1 Body mass index
AB Objective. To evaluate the prevalence of endometrial polyps in obese asymptomatic pre and postmenopausal patients with breast cancer and to know if a baseline pretamoxifen endometrial assessment should be taken into consideration in these women at high risk.Methods. A cross-sectional study was carried out with 201 women with breast cancer. A diagnostic hysteroscopy was performed in all women. All formations suspected as polyps were removed. The prevalence of endometrial polyps was analyzed in all patients (n = 182) and in premenopausal (n = 49) and postmenopausal (n = 118) women with estrogen receptor (ER) positive breast cancer (BC) according to their body mass index (BMI) and other risk factors.Results. Hysteroscopic evaluation was possible in 182 cases (90.5%). Of the total of women, 160 (87.9%) were ER(+)BC patients, 133 (73.1%) postmenopausal women and 41.5% were obese (BMI ≥ 30 kg/m2). Endometrial polyps were found in 52 cases (28.5%) (3 cases of simple hyperplasia harbored within a polyp). In premenopausalpatients with ER(+)BC, there were no statistical differences in endometrial polyps according to their BMI (22.3% in non-obese women vs 31.7% in obese) while in all patients (26.4% in non-obese vs 44.0% in obese) and in postmenopausal women with ER(+)BC (25.9% in non-obese vs 48.6% in obese) there were statistical differences. In all women the relative risk (RR) of endometrial polyps in obese patients was 2.24 (1.01–4.83), in obese postmenopausal women with ER(+)BC was 2.75 (1.01–7.40) and in obese premenopausal patients with ER(+) BC was 1.42 (0.80–3.29).Conclusions. Asymptomatic women with breast cancer have a high prevalence of baseline subclinical endometri- al polyps and it is very high in obese postmenopausal patients with estrogen receptor positive breast cancer. Therefore, there may be a future role for baseline pretamoxifen screening of some sort for the obese asymptomatic postmenopausal patient, especially if they are elderly and ER positive.
PB Elsevier
SN 1095-6859
YR 2014
FD 2014-01
LK http://hdl.handle.net/10498/38394
UL http://hdl.handle.net/10498/38394
LA eng
NO Ninguno
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026