RT journal article
T1 Baseline hysteroscopic assessment of endometrium in asymptomatic postmenopausal women with estrogen receptor positive breast cancer
T2 Evaluación histeroscópica basal del endometrio en mujeres posmenopáusicas asintomáticas con cáncer de mama con receptores de estrógenos positivos
A1 Lubián López, Daniel María
A1 González Fernández, Yurena
A1 Vilar Sánchez, Angel
A1 Iglesias Álvarez, María
A1 López Reynaldo, María Isabel
A1 Comino Delgado, Rafael
A2 Materno-Infantil y Radiología
K1 Breast cancer
K1 Postmenopausal
K1 Endometrial pathology
K1 Body mass index
K1 Hysteroscopy
AB Objective: The goal of this study was to evaluate the true prevalence of endometrial pathology in asymptomatic postmenopausal estrogen receptorYpositive (ER-positive) breast cancer patients and to know whether some patients are particularly at risk.Methods: A preliminary cross-sectional study was carried out with 130 postmenopausal ER-positive breast cancer patients. Before any treatment, diagnostic hysteroscopy and endometrial biopsy were performed in all women. Histopathological findings were considered the gold standard in estimating the prevalence of endometrial disease, which was analyzed according to different risk factors.Results: Hysteroscopic evaluation was possible in 118 patients (90.7%). Of these patients, 68.6% were older than 60 years, and 51.4% were obese. Endometrial polyps were found in 35 patients (29.6%; 1 polyp with simple hyperplasia), and simple endometrial hyperplasia was found in 1 patient (0.8%), with an overall morbidity of the endometrium of 31.3%. Among all the well-established individual risk factors for endometrial pathology, only patient age, body mass index, and time since menopause were significant predictors of endometrial pathology and/or polyps. There was no statistical difference in the thicknesses of the endometrial lining, but many patients with an endometrial lining of less than 4 mm had polyps of less than 5 mm.Conclusions: Asymptomatic postmenopausal women with ER-positive breast cancer have a very high prevalence of baseline subclinical endometrial abnormalities. Therefore, endometrial screening before tamoxifen treatment may be useful in all of these patients, and we believe that it should be performed by hysteroscopy in patients at high risk (obese and older women).
PB Lippincott Williams & Wilkins
SN 1072-3714
YR 2013
FD 2013-01
LK http://hdl.handle.net/10498/38401
UL http://hdl.handle.net/10498/38401
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026