RT journal article
T1 Sex-Related Differences in Patient Characteristics, Risk Factors, and Symptomatology in Older Adults with Pulmonary Embolism: Findings from the SERIOUS-PE Study
A1 Bikdeli, Behnood
A1 Muriel, Alfonso
A1 Wang, Yun
A1 Piazza, Gregory
A1 Khairani, Candrika D
A1 Rosovsky, Rachel P.
A1 Mehdipoor, Ghazaleh
A1 O’Donoghue, Michelle L.
A1 Madridano, Olga
A1 López Sáez, José Juan Bosco
A1 Mellado, Meritxell
A1 Diaz Brasero, Ana Maria
A1 Grandone, Elvira
A1 Spagnolo, Primavera A.
A1 Lu, Yuan
A1 Bertoletti, Laurent
A1 López-Jiménez, Luciano
A1 Núñez, Manuel Jesús
A1 Blanco-Molina, Ángeles
A1 Gerhard-Herman, Marie
A1 Goldhaber, Samuel Z.
A1 Bates, Shannon M.
A1 Jimenez, David
A1 Krumholz, Harlan M.
A1 Monreal, Manuel
A2 Medicina
K1 sex
K1 comorbidity
K1 risk factory
K1 pulmonary embolism
K1 elderly
K1 symptomatology
AB Sex-specific factors are implicated in pulmonary embolism (PE) presentation in young patients, as indicated by increased risk in pregnancy. Whether sex differences exist in PE presentation, comorbidities, and symptomatology in older adults, the age group in which most PEs occur, remains unknown. We identified older adults (aged ≥65 years) with PE in a large international PE registry replete with information about relevant clinical characteristics (RIETE registry, 2001-2021). To provide national data from the United States, we assessed sex differences in clinical characteristics and risk factors of Medicare beneficiaries with PE (2001-2019). The majority of older adults with PE in RIETE (19,294/33,462, 57.7%) and in the Medicare database (551,492/948,823, 58.7%) were women. Compared with men, women with PE less frequently had atherosclerotic diseases, lung disease, cancer, or unprovoked PE, but more frequently had varicose veins, depression, prolonged immobility, or history of hormonal therapy (p < 0.001 for all). Women less often presented with chest pain (37.3 vs. 40.6%) or hemoptysis (2.4 vs. 5.6%) but more often with dyspnea (84.6 vs. 80.9%) (p < 0.001 for all). Measures of clot burden, PE risk stratification, and use of imaging modalities were comparable between women and men. PE is more common in elderly women than in men. Cancer and cardiovascular disease are more common in men, whereas transient provoking factors including trauma, immobility, or hormone therapy are more common in elderly women with PE. Whether such differences correlate with disparities in treatment or differences in short- or long-term clinical outcomes warrants further investigation.
PB THIEME groups
SN 0094-6176
YR 2023
FD 2023-03-03
LK http://hdl.handle.net/10498/38416
UL http://hdl.handle.net/10498/38416
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026