RT journal article
T1 Plasticity-Induced Motor Recovery of Bilateral Intermittent Theta Burst Stimulation in Parkinson's Disease: A Randomized, Double-Blind, Sham-Controlled, Crossover Trial
A1 Rashid Abdu Rahim López, Raúl
A1 Macías García, Paloma
A1 Cruz Gómez, Álvaro Javier
A1 Cano Cano, Fátima
A1 Sánchez Fernández, Francisco Luis
A1 Sarrias Arrabal, Esteban
A1 Marco Delgado, Ángel José del
A1 González Moraleda, Álvaro Antonio
A1 Lozano Soto, Elena María
A1 Sanmartino, Florencia Soledad
A1 Espinosa Rosso, Raúl
A1 González Rosa, Javier Jesús
A2 BiomedicinaBiotecnología y Salud Pública
K1 Intermittent theta burst stimulation
K1 Neurodegeneration and neuroplasticity serum biomarkers
K1 Parkinson’s disease
K1 Structural brain imaging
AB Cortico-subcortical dysfunction from dopaminergic depletion is a hallmark of Parkinson's disease (PD). Modulating primary motor cortex (M1) excitability with intermittent theta burst stimulation (iTBS) may restore network integrity in PD by targeting neurobiological changes at excitatory, structural, and serological levels. This study aimed to demonstrate the clinical and neurobiological effects of bilateral M1 iTBS in patients with PD.Bilateral M1 iTBS may represent a valuable adjunctive therapeutic option for pharmacological treatment of motor symptoms in patients with PD by promoting structural brain changes and enhancing synaptic plasticity in intermediate disease stages.
PB Springer Nature
SN 2193-6536
YR 2026
FD 2026
LK http://hdl.handle.net/10498/38602
UL http://hdl.handle.net/10498/38602
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026