RT journal article
T1 Exploring a Novel Anti-Inflammatory Therapy for Diabetic Retinopathy Based on Glyco-Zeolitic-Imidazolate Frameworks
A1 Díaz-Paredes, E.
A1 Martín Loro, Francisco
A1 Rodríguez-Marín, R.
A1 Gómez Jaramillo, María Laura
A1 Sánchez-Fernández, Elena M.
A1 Carrillo-Carrión, Carolina
A1 Arroba Espinosa, Ana Isabel
A2 Anatomía y Embriología Humana
A2 BiomedicinaBiotecnología y Salud Pública
K1 glycolipid
K1 zeolitic-imidazolate framework
K1 microglia
K1 inflammation
K1 immunemediated therapy
K1 diabetic retinopathy
AB Background/Objectives: Diabetic retinopathy is an ocular disease caused bychanges in the expression of inflammatory mediators and increased oxidative stress in theretina and is the leading cause of vision loss in diabetic patients. Currently, there is notreatment capable of reversing retinal damage, which represents a significant burden onthe quality of life of patients. (1R)-1-Dodecylsulfonyl-5N,6O-oxomethylidenenojirimycinstands outs as a prototype of the sp2-iminoglycolipids family for its beneficial neuroprotective effect against this chronic eye disease. Critical issues related to the low solubility andbioavailability of this glycolipid in biological settings are overcome by its encapsulation in aZeolitic-Imidazolate Framework (ZIF) structure, resulting in homogeneous and biocompatible GlycoZIF nanoparticles. Cell studies show an enhanced cellular uptake compared withthe free glycolipid, and importantly, its bioactivity is preserved once released inside cells.Methods: Extensive in vitro and ex vivo assays with diabetic retinopathy models unveilthe mechanistic pathways of the designed GlycoZIF. Results: A reduction in proinflammatory mediators, increased heme oxygenase-1 level, inhibition of NLRP3 inflammasome,and reduced reactive gliosis is shown. Conclusions: These findings demonstrate for thefirst time the potential of Glyco-modified ZIFs for the treatment of diabetes-related ocularproblems by controlling the immune-mediated inflammatory response.
PB MDPI
SN 1999-4923
YR 2025
FD 2025-06-17
LK http://hdl.handle.net/10498/38619
UL http://hdl.handle.net/10498/38619
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026