RT journal article
T1 Supercritical Impregnation of Olive Leaf Extract in Poly(L-lactic acid-co-caprolactone) Filaments: An Environmentally Friendly Approach to Obtaining Active Biomedical Materials
A1 Montes Lobato, Juan Ramón
A1 Machado,  Noelia Daiana
A1 Cejudo Bastante, Cristina
A1 Mantell Serrano, Casimiro
A1 Casas Cardoso, Lourdes
A2 Ingeniería Química y Tecnología de Alimentos
K1 active compound delivery systems
K1 olive leaf extract
K1 poly(L-lactic-co-caprolactone) (PLCL)
K1 supercritical fluid
AB The valorization of by-products in the olive sector has increasingly become the focus of business and research in the context of biorefineries. This work evaluates the recovery of bioactive compounds from olive leaves and their subsequent incorporation into poly(L-lactic- acid-co-caprolactone) (PLCL) filaments through supercritical impregnation. Obtaining an olive leaf extract (OLE) using enhanced solvent extraction at a high pressure (ESE with CO2/ethanol 1:1 v/v) resulted in higher yields and concentrations of bioactives with high antioxidant and anti-inflammatory activity. No significant differences were found between the extracts obtained with different water regimes (irrigated and dry land). The supercritical impregnation of PLCL filaments showed that a low depressurization rate is essential to avoid material deformation, while the impregnation pressure and temperature influenced the OLE loading and antioxidant activity of the filaments. In vitro release studies showed the prolonged release of active compounds over 90 days, and the kinetics best fit the Korsmeyer–Peppas model, suggesting a diffusion mechanism. These results validate supercritical impregnation as a promising strategy for the development of OLE-active PLCL filaments with potential for biomedical applications requiring sustained therapeutic release.
PB Multidisciplinary Digital Publishing Institute (MDPI)
SN 2073-4360
YR 2025
FD 2025
LK http://hdl.handle.net/10498/38728
UL http://hdl.handle.net/10498/38728
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026