RT journal article
T1 Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline
A1 Little, Karis
A1 Llorián-Salvador, María
A1 Scullion, Sarah
A1 Hernández, Cristina
A1 Simó-Servat, Olga
A1 Marco Delgado, Ángel José del
A1 Bosma, Esmeralda
A1 Vargas Soria, María
A1 Carranza Naval,  María José
A1 Van Bergen, Tine
A1 Galbiati, Silvia
A1 Viganò, Ilaria
A1 Musi, Clara Alice
A1 Schlingemann, Reiner
A1 Feyen, Jean
A1 Borsello, Tiziana
A1 Zerbini, Gianpaolo
A1 Klaassen, Ingeborg
A1 García Alloza, Mónica
A1 Simó, Rafael
A1 Stitt, Alan W.
A2 BiomedicinaBiotecnología y Salud Pública
K1 Alzheimer’s disease
K1 Cognitive decline
K1 Diabetes
K1 Neurovascular unit
AB Type 2 diabetes (T2D) is associated with multiple comorbidities, including diabetic retinopathy (DR) and cognitive decline, and T2D patients have a significantly higher risk of developing Alzheimer's disease (AD). Both DR and AD are characterized by a number of pathological mechanisms that coalesce around the neurovascular unit, including neuroinflammation and degeneration, vascular degeneration, and glial activation. Chronic hyperglycemia and insulin resistance also play a significant role, leading to activation of pathological mechanisms such as increased oxidative stress and the accumulation of advanced glycation end-products (AGEs). Understanding these common pathways and the degree to which they occur simultaneously in the brain and retina during diabetes will provide avenues to identify T2D patients at risk of cognitive decline.
PB Elsevier
SN 1043-2760
YR 2022
FD 2022
LK http://hdl.handle.net/10498/38787
UL http://hdl.handle.net/10498/38787
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026