RT journal article
T1 Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants.
A1 Roodveldt, Cintia
A1 Labrador, Adahir
A1 Gonzalez-Rey, Elena
A1 Fernández Montesinos, Rafael
A1 Caro, Marta
A1 Lachaud, Christian
A1 Waudby, Christopher
A1 Delgado, Mario
A1 Dobson, Christopher
A1 Pozo, David
A2 Anatomía y Embriología Humana
AB Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized pathologically by the presence in the brain of intracellular protein inclusions highly enriched in aggregated alpha-synuclein (α-Syn). Although it has been established that progression of the disease is accompanied by sustained activation of microglia, the underlying molecules and factors involved in these immune-triggered mechanisms remain largely unexplored. Lately, accumulating evidence has shown the presence of extracellular α-Syn both in its aggregated and monomeric forms in cerebrospinal fluid and blood plasma. However, the effect of extracellular α-Syn on cellular activation and immune mediators, as well as the impact of familial PD-linked α-Syn mutants on this stimulation, are still largely unknown
PB Plos One
SN 1932-6203
YR 2010
FD 2010-10-26
LK http://hdl.handle.net/10498/38862
UL http://hdl.handle.net/10498/38862
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026