RT journal article
T1 Baseline Hemoglobin Values and Clinical Outcomes in Acute Venous Thromboembolism: Insights From the RIETE Registry
A1 Siniscalchi, Carmine
A1 Di Micco, Pierpaolo
A1 Tufano, Antonella
A1 Peris, María Luisa
A1 López Miguel, Patricia
A1 Alda Lozano, Alicia
A1 Llamas, Pilar
A1 Durán Barata, Diego
A1 Jenab, Yaser
A1 Monreal, Manuel
A1 López Sáez, José Juan Bosco
A2 Medicina
K1 hemoglobin
K1 anemia
K1 bleeding risk
K1 enous thromboembolism
K1 prophylaxis
AB Venous thromboembolism (VTE) is a major global health concern and a leading cause of morbidity and mortality. While anticoagulation effectively reduces the risk of recurrent VTE, it is associated with an inherent risk of bleeding. Identifying patient characteristics that influence these risks is critical for personalized management. Baseline hemoglobin (Hb) values have emerged as a potential prognostic marker [1-5], reflecting both underlying comorbidities and hemostatic alterations. However, the impact of Hb values on both thrombotic and bleeding complications in anticoagulated VTE patients remains insufficiently characterized.We analyzed data from 111,646 patients with acute VTE included in the RIETE registry, a large multinational prospective cohort (ClinicalTrials.gov identifier: NCT02832245) [6]. Patients were stratified into Hb quintiles: < 11.4, 11.4–12.6, 12.7–13.6 (reference), 13.7–14.7, and > 14.7 g/dL. We assessed 90-day rates of recurrent VTE, major bleeding, arterial ischemic events (myocardial infarction, ischemic stroke, or limb amputation), and all-cause mortality. Multivariable logistic regression models were adjusted for demographic and clinical characteristics, including VTE risk factors, initial VTE presentation, comorbidities, renal function, leukocyte and platelet counts, anticoagulant strategy, and concomitant medications.
PB WILEY
SN 0361-8609
YR 2025
FD 2025
LK http://hdl.handle.net/10498/38991
UL http://hdl.handle.net/10498/38991
LA eng
NO ClinicalTrials.gov identifier: NCT02832245
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026