RT journal article
T1 Bioavailability, oxidative stress, neurotoxicity and genotoxicity of pharmaceuticals bound to marine sediments. The use of the polychaete Hediste diversicolor as bioindicator species
A1 Maranho, L.A.
A1 Baena Nogueras, Rosa María
A1 Lara Martín, Pablo Antonio
A1 Valls Casillas, Tomás Ángel del
A1 Martín Díaz, María Laura
A2 Química Física
K1 Polychaetes
K1 Marine sediments
K1 Pharmaceuticals
K1 Enzymatic activities
K1 Oxidative stress
AB A set of “early warning responses”, measured as biomarkers of exposure and effect, was applied in themarine bioindicator Hediste diversicolor, in a way to assess the environmental quality of sedimentaffected by pharmaceutical contamination.Sublethal responses were determined in the sea-worms after14-days of exposure to sediment spiked with some of the most representative pharmaceutical productsfound in the environment: carbamazepine (CBZ),ibuprofen (IBP), fluoxetine (FX),17α-ethynylestradiol(EE2) and propranolol (PRO), including the environmental concentrations. Phases I(ethoxyresorufin O-deethylase – EROD and dibenzyl fluorescein dealkylase – DBF) and II(glutathione S-transferase – GST) ofthe metabolism, antioxidant system(glutathioneperoxidase – GPX and glutathione reductase – GR),neurotoxicity (acetylcholinesterase – AChE)and oxidative effects (lipidperoxidation – LPO and DNAdamage strand breaks) were selected to evaluate the sublethaL responses in the sea-worms.FX,EE2 andPRO were detoxified by the phase I of the metabolism (EROD activity).On the other hand, phase II (GST-activity) did not respond in sea-worms exposed to pharmaceutical products, except for the environmental concentrations of CBZ (activation) and PRO (deactivation).Neurotoxicity was induced in sea-worms exposed to EE2 (only the environmental concentrations),FX, IBP and CBZ. Oxidative effectdetermined as LPO increased in sea-worms exposed to environmental concentrations of IBP, EE2 andPRO. Genetic damage increased in sea-worms exposed to IBP and diminished for FX, EE2 and PRO. Ourresults indicated the toxicity of pharmaceutical products and recommended the battery of biomarkersand the bioindicator specie H. diversicolor for the environmental quality assessment of sediment affected by pharmaceutical contamination.
PB Elsevier
SN 1096-0953
YR 2014
FD 2014
LK http://hdl.handle.net/10498/39043
UL http://hdl.handle.net/10498/39043
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 05-nov-2026