RT journal article
T1 Bioactive polydioxanone filaments functionalized with Olea europaea extract: Supercritical solvent impregnation, characterization and release profile
A1 Verano Naranjo, Lidia
A1 Machado,  Noelia Daiana
A1 Cejudo Bastante, Cristina
A1 Casas Cardoso, Lourdes
A1 Freire, Carmen S.R.
A1 Vilela, Carla
A1 Mantell Serrano, Casimiro
A2 Ingeniería Química y Tecnología de Alimentos
K1 Natural bioactive compounds
K1 Oleuropein
K1 Controlled release
K1 Polymeric delivery systems
K1 Antioxidant activity
K1 Lipoxygenase inhibition
AB The development of polymeric systems loaded with natural compounds is gaining momentum as a strategy for designing therapeutic materials, especially when combined with environmentally friendly technologies such as supercritical solvent impregnation (SSI). Olive leaf extract (OLE), particularly rich in oleuropein, offers potent antioxidant and anti-inflammatory effects. This study explores for the first time the SSI of OLE into polydioxanone (PDO) filaments, a biocompatible polymer commonly used in biomedical applications. The extract used, with 181.08 mg g−1 of oleuropein, demonstrated robust biological activity (DPPH IC50: 16.8 ± 1.4 mg L−1; LOX IC50: 207.2 ± 22.8 mg L−1). Processing conditions (pressure and temperature) were optimized to maximize extract incorporation, achieving the highest loading (15.05 ± 2.88 mg g−1) at 400 bar and 75 °C. Release assays performed in simulated physiological fluid (pH 7.4) revealed a diffusion-dominated mechanism. The active molecules retained their bioactivity post-release, with the in situ generation of the highly potent derivative, hydroxytyrosol. These findings support the potential of SSI as a platform for producing functional PDO-based systems with enhanced long-term therapeutic properties.
PB Elsevier
SN 2468-5194
YR 2025
FD 2025-12
LK http://hdl.handle.net/10498/39082
UL http://hdl.handle.net/10498/39082
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026