RT journal article
T1 Rab Proteins as Potential Therapeutic Targets Applied to Crustacean Aquaculture: Rab7 Case Analysis
A1 Fajardo Quiñones, Carlos
A1 De Donato, Marcos
A1 Charoonnart, Patai
A1 Saksmerprome, Vanvimon
A1 Jackson, Harry O.
A1 Mancera Romero, Juan Miguel
A1 Costas, Benjamín
A2 Biología
K1 antiviral
K1 gene therapy
K1 immunology
K1 shrimp
K1 therapeutic target
AB Rab proteins constitute an important subfamily of molecular effectors whose function is related to the modulation of several important cellular and metabolic processes, including controlling intracellular endocytic vesicle trafficking, phagosome formation, endosome maturation, and innate immunity. In crustaceans, the study and characterization of these proteins have garnered great interest, mainly due to their pivotal role in the innate immune response mechanisms against infections. Among the Rab family, the Rab7 stands out as a prominent example of the potential of these proteins as therapeutic targets for the development of genetic therapies to control viral pathogens in crustacean aquaculture. In this review, a compendium of the information currently available in relation to Rab proteins in crustaceans is made, taking the Rab7 protein as a model, emphasizing not only its general aspects of functioning at the molecular level, but also describing in- depth both mechanisms of action and potential interactions, as well as its implications in relation to the immune system, particularly in shrimp.
PB John Wiley and Sons Inc
SN 1753-5131
YR 2025
FD 2025-01
LK http://hdl.handle.net/10498/39156
UL http://hdl.handle.net/10498/39156
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026