RT journal article
T1 Clinical and Prognostic Significance of Parotid Scintigraphy in 405 Patients with Primary Sjögren’s Syndrome
A1 Ramos-Casals, Manuel
A1 Brito Zeron, Pilar
A1 Perez de Lis, Marta
A1 Diaz Lagares, Candido
A1 Bove, Albert
A1 Soto Cardenas, María José
A1 Jimenez, Iratxe
A1 Belenguer, Rafael
A1 Siso, Antoni
A1 Muxi, Africa
A1 Pons, Francesca
A2 Cirugía
A2 Medicina
K1 Lymphoma
K1 Mortality
K1 Parotid scintigraphy
K1 Sjögren's syndrome
AB Objective. To evaluate the association between the degree of involvement shown by parotid scintigraphy at diagnosis and the disease expression, outcomes, and prognosis of primary Sjögren’s syndrome (SS).Methods. All patients consecutively diagnosed with primary SS in our department between 1984 and 2008 were evaluated. The scintigraphic stages were classified into class 4 (severe involvement), class 2–3 (mild to moderate involvement), and class 1 (normal results).Results. A total of 405 patients with primary SS underwent parotid scintigraphy at diagnosis (47 had class 1 involvement, 314 had class 2–3, and 44 had class 4). Patients with class 4 had a higher frequency of parotid enlargement (p < 0.001), systemic involvement (p = 0.007), high titers of antinuclear antibody (p = 0.016), positive rheumatoid factor (p = 0.002), anti-Ro/SSA (p = 0.001), anti-La/SSB (p = 0.001), low C4 levels (p = 0.001), and low CH50 (p = 0.001) in comparison with the other 2 groups. A higher rate of lymphoma development was observed in patients with class 4 involvement. Adjusted multivariate Cox regression analysis showed a hazard ratio (HR) of 10.51 (p = 0.002) and Kaplan–Meier analysis a log-rank of 0.0005. Mortality was 5-fold higher in patients with class 4 involvement. Adjusted multivariate Cox regression analysis showed an HR of 5.33 (p = 0.001) and Kaplan-Meier analysis a log-rank of 0.033.Conclusion. Patients with SS presenting with severe scintigraphic involvement at diagnosis had a more pronounced autoimmune expression, a higher risk of developing systemic features and lymphoma, and a lower survival rate. Study of the degree of salivary gland dysfunction at diagnosis by parotid scintigraphy offers valuable clinical information on the prognosis and outcome of primary SS.
PB Journal of Rheumatology
SN 0315-162X
YR 2010
FD 2010-03
LK http://hdl.handle.net/10498/39215
UL http://hdl.handle.net/10498/39215
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026