RT journal article
T1 Bronchiectasis in primary Sjögren's syndrome: prevalence and clinical significance
A1 Soto Cardenas, María José
A1 Perez de Lis, Marta
A1 Bove, Albert
A1 Navarro, Carmen
A1 Brito Zeron, Pilar
A1 Diaz Lagares, Candido
A1 Gandia, Miriam
A1 Akasbi, Miriam
A1 Siso, Antoni
A1 Ballester, E.
A1 Torres, A.
A1 Ramos-Casals, Manuel
A2 Cirugía
A2 Medicina
K1 Bronchiectasis
K1 Pulmonary involvement
K1 Sjogren's syndrome
AB OBJECTIVES:To analyse the prevalence and clinical significance of bronchiectasis in a large series of patients with primary Sjögren`s syndrome (SS) and evaluate its impact on disease expression and outcomes.METHODS:The study cohort included 507 patients with primary SS. Bronchiectasis were diagnosed according to pulmonary computed tomography (CT). As a control group, we included 37 consecutive SS patients evaluated by pulmonary CT during the same study period without pulmonary involvement.RESULTS:Fifty primary SS patients had bronchiectasis according to the pulmonary CT. Nine patients were excluded due to non-autoimmune processes and 41 were classified as bronchiectasis associated with primary SS (40 women, mean age of 64 years). All cases of bronchiectasis were of the cylindrical type and were located in the inferior lobes in 29 cases (71%). Patients with bronchiectasis were older at diagnosis of SS (60.39 vs. 52.54 years, p=0.022) and had a higher frequency of hiatus hernia (41% vs. 16%, p=0.024) in comparison with controls. Immunologically, patients with bronchiectasis had a lower frequency of anti-Ro/SS-A antibodies (27% vs. 54%, p=0.022) but a higher frequency of anti-smooth muscle – SMAantibodies (82% vs. 60%, p=0.043). During follow-up, patients with bronchiectasis had a higher frequency of respiratory infections (56% vs. 3%, p<0.001) and pneumonia (29% vs. 3%, p=0.002) in comparison with those without.CONCLUSIONS:Patients with primary SS and bronchiectasis are characterised by an older age, a high frequency of hiatus hernia, a specific immunologic pattern (low frequency of anti-Ro/SS-A and high frequency of anti-SMA) and during follow-up a much higher frequency of respiratory infections and pneumonia.
PB Clinical and Experimental Rheumatology
SN 1593-098X
YR 2010
FD 2010
LK http://hdl.handle.net/10498/39218
UL http://hdl.handle.net/10498/39218
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026