RT journal article
T1 Tailoring Antioxidant Activities: Metal-Type Dependent, Highly Active SOD or Catalase Mimetics
A1 Martínez Camarena, Álvaro
A1 Navarro Madramany, Pablo
A1 Castillo González, Carmen Esther
A1 Doménech-Carbó, Antonio
A1 García Basallote, Manuel
A1 Faller, Peter
A1 García España, Enrique
A2 Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica
K1 Biomimetic Materials
K1 Antioxidant activities
K1 Hydrogen Peroxide
K1 Molecular Structure
K1 Pyridines
K1 Superoxide Dismutase
K1 Superoxides
AB The failure of the therapeutic administration of superoxide dismutase (SOD) and catalase (CAT) enzymes to prevent oxidative stress has fostered the development of metal complexes that are capable of mimicking their activity. In the present work, two new pyridine azacyclophane ligands capable of coordinating Cu2+and Fe2+to give rise to mimetics with high activities toward disproportionation of the superoxide anion or hydrogen peroxide, depending on the metal ion, have been prepared. Although the Cu2+complexes have some of the highest SOD activities reported to date, they are completely inactive toward H2O2disproportionation. In contrast, the Fe2+complexes catalyze the disproportionation of H2O2without showing any catalytic SOD activity. Therefore, the type of antioxidant activity of these macrocycles is dictated by the nature of the metal ion, which represents a new approach to the development of potentially useful mimetics.
PB American Chemical Society
SN 1520-510X
YR 2025
FD 2025
LK http://hdl.handle.net/10498/39302
UL http://hdl.handle.net/10498/39302
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026