RT journal article
T1 Synthesis of Farnesyloxy- and Drimanyloxy-Arene Scaffold-Based Hybrid Molecules as Antifungals against Botrytis cinerea
A1 Ruano González, Antonio
A1 Pinto, Ana Andreina
A1 Mancilla, Gabriela
A1 Sánchez Maestre, Rosario
A1 Aleu, Josefina
A1 Hernández Galán, Rosario
A1 Macías Sánchez, Antonio José
A1 González Collado, Isidro
A2 Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica
A2 Química Orgánica
K1 Botrytis cinerea
K1 phytopathogenic fung
K1 antifungal
K1 hybrid molecules
K1 farnesyloxyarenes
K1 drimanyloxyarenes
AB There is an increasing interest in the use of biopesticides, which implies the use of living microorganisms, plant andmicrobial extracts, and natural products isolated from the above-mentioned sources or closely related derivatives. In this regard, 10farnesyloxy-arenes derivatives (21−25, (±)-26−(±)-30) and 12 drimanyloxyarenes derivatives ((±)-12−(±)-14, (±)-31−(±)-40)were synthesized and tested against the phytopathogenic fungus Botrytis cinerea. In general, the drimanyloxyarenes derivatives weremore fungitoxic than their farnesyloxyarene precursors. The most active compounds were (±)-12, (±)-31, and (±)-35, which at a391 × 10−5 mg/mL dose, were more active than azoxystrobin, while (±)-12 presented an inhibition comparable to that of triclosan.Structure−activity relationships are discussed, as well as the correlation with calculated physicochemical properties such as logP andtotal polar surface area.
PB American Chemical Society
SN 1520-5118
YR 2025
FD 2025
LK http://hdl.handle.net/10498/39311
UL http://hdl.handle.net/10498/39311
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026