RT journal article
T1 Phytochemical, Ethnobotanical, Pharmacological, and Toxicological Profile of Globularia alypum L.: A Comprehensive Review
A1 Asraoui, Fadoua
A1 Ben Said, Mariem
A1 El Mansouri, Nabila
A1 Bakkali, Imane
A1 Sakar, El Hassan
A1 Bakha, Mohamed
A1 Ortiz Liébana, Noemí
A1 Cacciola, Francesco
A1 Louajri, Adnane
A1 Palma Lovillo, Miguel
A1 Brigui, Jamal
A1 El Mansouri, Fouad
A2 Química Analítica
K1 Globularia. alypum L
K1 traditional uses
K1 herbal medicine
K1 phytochemistry
K1 bioactive compounds
K1 pharmacology
AB Globularia alypum L. (Plantaginaceae) is widespread in the Mediterranean region and traditionally used against diabetes, digestive disorders, infections, and skin problems. Thisreview summarizes its botanical features, ethnobotanical uses, phytochemistry, pharmacological effects, and toxicological profile. Relevant studies published between 1991 and2024 were retrieved from Web of Science, Scopus, PubMed, and other relevant databasesusing targeted keywords in English and French. Extracts of G. alypum have shown significant antidiabetic, antioxidant, anticancer, antibacterial, anti-inflammatory, anticoagulant,nephroprotective, and wound-healing activities in vitro and in vivo, which were largelyattributed to its diverse secondary metabolites such as phenolics, flavonoids, and iridoids.Toxicological studies indicate generally low risk at tested doses. However, further researchis needed to elucidate the molecular mechanisms underlying these activities, validate itsefficacy through clinical trials, and evaluate long-term safety, thereby bridging traditionalknowledge with modern pharmacological evidence.
PB MDPI
SN 2223-7747
YR 2025
FD 2025
LK http://hdl.handle.net/10498/39318
UL http://hdl.handle.net/10498/39318
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026