RT journal article
T1 Outcomes and predictors of mortality in patients with severe COVID-19 and COPD admitted to ICU: A multicenter study
A1 Fernández Barat, Laia
A1 Motos, Ana
A1 Canseco Ribas, Joan
A1 Gabarrús, Albert
A1 López Aladid, Rubén
A1 Álvaro Meca, Alejandro
A1 Ceccato, Adrián
A1 García, Nadia
A1 Ferrer, Miquel
A1 Battaglini, Denise
A1 Ávarez-Napagao, Sergio
A1 GarcÍa Gasulla, Dario
A1 Ferrer, Ricard
A1 de Gonzalo Calvo, David
A1 Lorente, José Ángel
A1 Menéndez, Rosario
A1 Peñuelas, Oscar
A1 Riera, Jordi
A1 Rodrıíguez, Alejandro
A1 Amaya Villar, Rosario
A1 Añón, José M.
A1 Balan Mariño, Ana
A1 Barberà, Carme
A1 Barberán, José
A1 Blandino Ortiz, Aaron
A1 Boado, Maria Victoria
A1 Bofill, Neus
A1 Bustamante Munguira, Elena
A1 Caballero, Jesús
A1 Cantón-Bulnes, María Luisa
A1 Carbajales Pérez, Cristina
A1 Carbonell, Nieves
A1 Catalán González, Mercedes
A1 de la Torre, Maria del Carmen
A1 Díaz, Emili
A1 Estella García, Ángel
A1 Figueras, Albert
A1 de Frutos, Raul
A1 Franco, Nieves
A1 Galbán, Cristóbal
A1 Gallego, Elena
A1 García Garmendia, José Luis
A1 González, Jessica
A1 Gómez, José M.
A1 Gumucio-Sanguino, Víctor D.
A1 Huerta, Arturo
A1 Jorge García, Ruth Noemí
A1 Loza Vázquez, Ana
A1 Marin Corral, Judith
A1 Martin Delgado, María Cruz
A1 Martínez de la Gándara, Amalia
A1 Martínez Varela, Ignacio
A1 Albaiceta, Guillermo M.
A1 Nieto, Maite
A1 Peñasco, Yhivian
A1 Pérez Bastida, Leire
A1 Pérez García, Felipe
A1 Pozo Laderas, Juan Carlos
A1 Ricart, Pilar
A1 Sagredo, Víctor
A1 Sánchez Miralles, Ángel
A1 Sancho Chinesta, Susana
A1 Socias, Lorenzo
A1 Solé Violan, Jordi
A1 Suárez Sipmann, Fernando
A1 Tamayo Lomas, Luis
A1 Trenado, José
A1 Úbeda, Alejandro
A1 Valdivia, Luis Jorge
A1 Vidal, Pablo
A1 Bermejo Martin, Jesús
A1 Barbe, Ferran
A1 Torres, Antoni
A2 Cirugía
A2 Medicina
K1 Chronic obstructive pulmonary disease
K1 Respiratory support
K1 Biomarkers
K1 Acute respiratory distress syndrome
K1 High flow nasal cannulas
AB Background: High mortality rates among patients with chronic obstructive pulmonary disease (COPD) admitted to intensive care units (ICUs) during the COVID-19 pandemic highlight the need for tailored clinical management strategies. Study Design and Methods: Epidemiological, clinical, and laboratory data were collected in REDCap for 6512 patients hospitalized with COVID-19 across 55 Spanish ICUs. Patients were stratified into three groups: those with COPD, those with other chronic respiratory diseases (CRD), and those without respiratory comorbidities (No CRD). The primary outcome was to determine clinical predictors for 90-day mortality, focusing on the COPD group. A propensity score matching (PSM) method was applied to analyze the effects of respiratory support, biomarkers, and immunomarkers. Results: Patients with COPD (n = 328) exhibited a 50% mortality rate compared to 33% of those with other chronic respiratory diseases (CRD, n = 547), and those without respiratory comorbidities (No CRD, n = 5124). Among COPD patients, 95% of whom had Acute Respiratory Distress Syndrome (ARDS) due to COVID-19, the use of a high-flow nasal cannula (HFNC) was associated with reduced 90-day mortality (hazard ratio: 0.54 (95% Confidence Interval [0.31–0.95]). At a molecular scale, lower IgG levels but higher viral load and TNF-alpha, Vascular Cell Adhesion Molecule-1 (VCAM-1), and Fas Cell Surface Death Receptor (Fas) were associated with mortality in the COPD group. Conclusions: In COPD patients with ARDS due to COVID-19, the use of HFNC was associated with a better prognosis. The dysregulation in biomarkers and immunomarkers in COPD patients and its association with mortality highlight the need for further targeted therapeutic strategies.
PB Elsevier
SN 2352-5568
YR 2025
FD 2025
LK http://hdl.handle.net/10498/39386
UL http://hdl.handle.net/10498/39386
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 05-nov-2026