RT journal article
T1 Pruritus and Pain Constitute the Main Negative Impact of Atopic Dermatitis From the Patient’s Perspective: A Systematic Review
A1 Armario Hita, José Carlos
A1 Carrascosa, José Manuel
A1 Flórez, Ángeles
A1 Herranz, Pedro
A1 Pereyra-Rodriguez, José-Juan
A1 Serra Baldrich, Esther
A1 Comellas, Marta
A1 Isidoro, Olga
A1 Ortiz de Frutos, Francisco Javier
A2 Cirugía
A2 Medicina
K1 Atopic dermatitis (AD)
AB Abstract: Atopic dermatitis (AD) is an inflammatory skin disease characterized by intense itching and highly visible signs, representing a great burden to the patient. Despite its straightforward diagnosis, AD severity and burden can be underestimated in routine clinical practice. This review aims to determine the impact of AD on patients’ lives, establish which domains of life are most affected, and identify symptom drivers of AD burden. A systematic literature review was conducted in Pubmed/Medline, Web of Science, and Scopus following Cochrane and PRISMA recommendations. Observational studies published in English or Spanish between January 1, 2018, and August 31, 2022, evaluating the impact of AD and its symptoms from the patient’s perspective, were included. Reviewed studies were assessed for quality following the STrengthening the Reporting of OBservational studies in Epidemiology Checklist. A total of 28observational studies evaluating the impact of AD and its symptoms from the patient’s perspective were included in the review. All domains of the AD patient’s life were found to be greatly affected, including health-related quality of life (HRQoL), emotional health, sleep disorders, work impairment, health care resource utilization, cognitive function, and development of comorbidities. The more severe the disease, the greater the impact, worsening in patients with moderate and severe AD. Pruritus and pain are reported to be the disease symptoms with the greatest impact. In conclusion, AD impacts several domains of patients’ lives, especially HRQoL and mental health. Pruritus and pain areidentified as the main drivers of AD impact, suggesting that optimal symptom control may reduce the burden and improve disease management.
PB American Contact Dermatitis Society
SN 2162-5220
YR 2023
FD 2023
LK http://hdl.handle.net/10498/39521
UL http://hdl.handle.net/10498/39521
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 09-nov-2026