RT journal article
T1 Mitochondrial Dysfunction Combined with Elevated CoQ10 Levels Specifically in Placental Cytotrophoblasts Suggests a Role for Mitophagy in Preeclampsia
A1 Abalos Martínez, Jessica
A1 Visiedo García, Francisco Manuel
A1 Cascajo Almenara, María Victoria
A1 Santos Rosendo, Celeste
A1 Melero Jiménez, Victoria
A1 Santos Ocaña, Carlos
A1 Vázquez Fonseca, Luis
A1 Bugatto González, Fernando
A2 Anatomía y Embriología Humana
A2 BiomedicinaBiotecnología y Salud Pública
A2 Materno-Infantil y Radiología
K1 preeclampsia
K1 mitochondria
K1 cytotrophoblast
K1 mitophagy
K1 coenzyme Q10
AB Preeclampsia is a severe pregnancy disorder associated with significant morbidity and mortality for both the mother and the baby. The causes underlying the development of preeclampsia remain unknown, but it is well established that the placenta is the organ that triggers the disease and that its mitochondrial metabolism is compromised. This study suggests that the cytotrophoblast is a placental cell type that is particularly affected at the mitochondrial level in preeclampsia. This mitochondrial dysfunction observed in this cell type is accompanied by an increase in coenzyme Q10 levels, which may represent a compensatory response. The data also suggest the activation of a second potential adaptive mechanism in cytotrophoblasts in response to mitochondrial dysfunction—mitophagy. This alteration and putative compensatory response were not observed in syncytiotrophoblasts. These findings highlight the possible specific involvement of the cytotrophoblast during preeclampsia, a cell type characterized by high mitochondrial activity within the placenta. Overall, these observations support the relevance of cytotrophoblast mitochondrial metabolism for future mechanistic studies aimed at better understanding preeclampsia.
PB MDPI
SN 2079-7737
YR 2026
FD 2026-01-13
LK http://hdl.handle.net/10498/39587
UL http://hdl.handle.net/10498/39587
LA eng
NO Instituto de Salud Carlos III (PI23/00439) y Plan Propio 2025 of INIBICA (Ref: PP25-TECL)
DS Repositorio Institucional de la Universidad de Cádiz
RD 05-nov-2026