RT journal article
T1 Methylation as an Effective Way to Generate SOD-Activity in Copper Complexes of Scorpiand-Like Azamacrocyclic Receptors
A1 Nebot-Guinot, Aida
A1 Liberato González, Andrea
A1 Máñez Muñoz, María Ángeles
A1 Clares, M. Paz
A1 Doménech-Carbó, Antonio
A1 Pitarch-Jarque, Javier
A1 García Basallote, Manuel
A1 García España, Enrique
A2 Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica
K1 SOD activity
K1 Kinetics
K1 Copper complexes
K1 Scorpiand-like azamacrocycles
AB Methylation of the secondary amine groups of a scorpiand-type ligand consisting of a pyridine spacer connected through methylene groups to a tris(2-aminomethyl) unit with the pendant arm further functionalised with a 3-pyridine unit leads to a ligand whose Cu(II) complex exhibits three-fold enhanced SOD activity with respect to the non-methylated ligand. Potentiometric studies indicate the formation of [CuL]2+ species with a stability three orders of magnitude lower than that formed with the related non-methylated ligand. Kinetic studies indicate that methylation of the secondary nitrogens causes a deceleration of both the complex formation and the acid-induced dissociation of the metal ion. The reduction in stability associated to the poorer -donor ability of the tertiary amino groups shifts the Cu(II)/Cu(I) redox potentials towards more positive values permitting a better cycling between both states needed for the dismutation of superoxide radicals.
PB Elsevier
SN 0020-1693
YR 2018
FD 2018-03
LK http://hdl.handle.net/10498/39684
UL http://hdl.handle.net/10498/39684
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 05-nov-2026