RT journal article
T1 Associations of cardiorespiratory fitness and muscular fitness with plasma levels of endocannabinoids and their analogues in adults with diagnosed depression: SONRIE study
A1 Ruiz Muñoz, Manuel
A1 Ortega Gómez, Sonia
A1 Espinosa Nogales, María del Mar
A1 Valmisa Gómez de Lara, Eulalio Juan
A1 Rosety Rodríguez, Miguel Ángel
A1 España Romero, Vanesa
A2 Didáctica de la Educación FísicaPlástica y Musical
A2 Neurociencias
K1 Cardiorespiratory fitness
K1 Cross-sectional study
K1 Depression
K1 Endocannabinoid system
K1 Muscular fitness
K1 Physical fitness
AB Background: Depression is a leading cause of global disability, affecting approximately 280 million individuals worldwide. Emerging evidence suggests that both physical fitness and endocannabinoids system play significant roles in the pathophysiology and management of depressive disorders.Purpose: To examine the associations between physical fitness, in terms of cardiorespiratory fitness (CRF) and muscular fitness (MF), with plasma levels of endocannabinoids (eCBs) and their analogues, in adults diagnosed with depression.Methods: The study involved 80 adults (ages 25-65) with a psychiatric diagnosis of mild-to-moderate depression based on the International Classification of Diseases 10th Revision (ICD-10) criteria. Physical fitness was assessed through tests measuring CRF (6-Minute Walk Test) and MF (Handgrip, Arm Curl, Chair Stand, Standing Long Jump Test). Fasting plasma levels of eCBs, such as anandamide (AEA) and 2-arachidonoyl glycerol (2-AG), and their analogues were measured using liquid chromatography-tandem mass spectrometry. Linear regression analyses were conducted or the associations between fitness variables and plasma levels of eCBs and their analogues using three models.Results: CRF and jump performance were inversely associated with plasma levels of the eCBs AEA (β range: - 0.302 to - 0.237 for CRF, - 0.315 to - 0.370 for jump; All p < 0.05) and 2-AG (β range: - 0.308 to - 0.326 across all models). eCBs analogues correlated negatively with CRF [2-linoleoylglycerol, 2-oleoylglycerol, docosatetraenoylethanolamide (DEA)] and jump (linoleylethanolamine, stearoylethanolamine, DEA); findings persisted after lean mass normalization.Conclusion: Our findings indicated that higher physical fitness was associated with lower plasma levels of eCBs and their analogues.
PB Springer
SN 0940-1334
YR 2025
FD 2025
LK http://hdl.handle.net/10498/39839
UL http://hdl.handle.net/10498/39839
LA eng
NO Funding for open access publishing: Universidad de Cádiz/CBUAThe SONRIE Study was funded by the Consejería de Salud y Familias, Junta de Andalucía, Spain (PI0068-2018). The funding sources had no involvement in the study design, data collection, analysis, interpretation of data, or the writing of the manuscript.
DS Repositorio Institucional de la Universidad de Cádiz
RD 09-nov-2026