RT journal article
T1 Inorganic Polyphosphate in Hematolymphoid Malignancies: Biological Rationale and Emerging Research Gaps
A1 García-Domínguez, Francisco
A1 Fernández Ponce, Cecilia Matilde
A1 Salb-Pernas, Carlota
A1 Santisteban Espejo, Antonio Leopoldo
A1 Ruiz Rodríguez, Félix Alejandro
A2 BiomedicinaBiotecnología y Salud Pública
A2 Cirugía
A2 Medicina
K1 polyphosphate
K1 hemostasis
K1 inflammation
K1 myeloma
K1 leukemia
K1 lymphoma
AB Inorganic polyphosphates (polyP) are linear phosphate polymers that play essential functions in human physiology, such as coagulation and inflammation. Despite their recognized participation in solid tumor progression, there are few data on hematolymphoid malignancies. Here, we conducted a narrative review of studies investigating polyP functions in mammalian biology, coagulation, and hematologic systems, focusing on research gaps in hematological oncology. PolyP modulates coagulation cascades, platelet activation, and cellular metabolism. In tumors, polyP has been reported to modulate immune responses and apoptosis in several experimental systems. Emerging data suggest participation in leukemic signaling and the bone marrow microenvironment. Direct evidence linking polyP to hematolymphoid neoplasms is scarce. Being biologically plausible, it represents a promising and largely unexplored area of research and an excellent opportunity for novel therapeutic approaches.
PB MDPI
SN 2218-273X
YR 2026
FD 2026-07-16
LK http://hdl.handle.net/10498/40204
UL http://hdl.handle.net/10498/40204
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026