RT journal article
T1 Cortical-Subthalamic Interplay During Eyes-Open and Eyes-Closed Resting States in Parkinson's Disease Patients
A1 Sanmartino, Florencia Soledad
A1 Rashid Abdu Rahim López, Raúl
A1 López Sosa, Fernando
A1 Cruz Gómez, Álvaro Javier
A1 Lozano Soto, Elena María
A1 Rique Dormido, Jesús
A1 Espinosa Rosso, Raúl
A1 González Rosa, Javier Jesús
A2 Psicología
K1 Local  field potentials (LFPs)
K1 electroencephalography (EEG)
K1 resting state
K1 functional connectivity
K1 Parkinson's disease (PD)
K1 deep brain stimulation (DBS)
AB Resting-state eye conditions modulate cortical oscillations, but their impact on subthalamic nucleus (STN) and cortico-STN dynamics in Parkinson's disease (PD) remains poorly understood. Here, we characterized electrophysiological changes in the STN and cortical interactions during eyes-open (EO) and eyes-closed (EC) conditions in 12 PD patients undergoing deep brain stimulation surgery. Spontaneous local field potentials in the STN (STN-LFP) and surface electroencephalogram (EEG) activity were simultaneously obtained on postoperative days 2-3 in the OFF-medication state. Power spectral density (PSD), coherence (COH), and Granger causality measures between STN-LFPs and frontal-occipital cortical areas were analyzed. These metrics revealed significant EO-EC differences, particularly in the low-frequency (LF, 4-12[Formula: see text]Hz) range. Although LF power increased across all regions during EC relative to EO, only STN and frontal EEG showed statistically significant changes. EC elicited increased frontal-STN COH within both the LF and low-beta bands (13-21[Formula: see text]Hz), accompanied by enhanced occipital-STN coupling in the low-beta range. In contrast, the influence of the alpha-band frontal cortex on the STN was more pronounced during EO. These findings confirm that eye states may differentially modulate functional connectivity through widespread cortical and STN-cortical interactions and suggest that, in unmedicated PD, EC and EO dynamically modulate large-scale cortical-STN network activity.
PB World Scientific, Vol. 36, No. 9 (2026) 2650031 (20 pages)
SN 0129-0657
YR 2026
FD 2026-09-01
LK http://hdl.handle.net/10498/40391
UL http://hdl.handle.net/10498/40391
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026