RT journal article
T1 A matched case-control study on Escherichia coli factors contributing to sepsis and septic shock in bacteraemic patients
A1 Maldonado, Natalia
A1 López-Hernández, Inmacualda
A1 Valik, John Karlsson
A1 López Cortés, Luis Eduardo
A1 Martínez Pérez-Crespo, Pedro María
A1 Garcia-Montaner, Andrea
A1 Alcalde-Rico, Manuel
A1 Sousa Dominguez, Adrián
A1 Jover Sáenz, Alfredo
A1 Goikoetxea Aguirre, Ane Josune
A1 Pulido Navazo, Ángeles
A1 Buzon-Martin, Luis
A1 Aller, Ana Isabel
A1 Boix Palop, Lucía
A1 del Arco Jiménez, Alfonso
A1 Smithson Amat, Alejandro
A1 Sánchez Calvo, Juan Manuel
A1 Natera Kindelán, Clara
A1 Reguera Iglesias, José María
A1 Armiñanzas Castillo, Carlos
A1 Galán Sánchez, Fátima
A1 Bahamonde Carrasco, Alberto
A1 Gea Lázaro, Isabel
A1 Castello-Abietar, Cristian
A1 Pérez Camacho, Inés
A1 Marrodán Ciordia, Teresa
A1 Becerril-Carral, Berta
A1 Naucler, Pontus
A1 Pascual-Hernandez, Álvaro
A1 Rodríguez Baño, Jesús
A1 López Hernández, Inmaculada
A1 Retamar Gentil, Pilar
A1 Pascual, Álvaro
A1 Lanz García, Joaquín
A1 León Jiménez, Eva
A1 Corzo-Delgado, Juan Enrique
A1 Pérez Rodríguez, María Teresa
A1 Barcenilla Gaite, Fernando
A1 Montejo Baranda, Miguel
A1 Cuquet Pedragosa, Jordi
A1 Labayru Echeverria, Cristina
A1 Mantecon Vallejo, María Ángeles
A1 Boix Palop, Lucía
A1 Calbo Sebastian, Esther
A1 Farinas Alvarez, María Del Carmen
A1 Fernández Suárez, Jonathan
A1 Arias Temprano, Marta
A1 Canueto Quintero, Jesús
A1 Reyes Bertos, Armando
A1 Sánchez Porto, Antonio
A1 Vinuesa García, David
A1 Guzmán García, Marcos
A1 Jiménez Aguilar, Patricia
A1 Pasquau, Juan
A2 BiomedicinaBiotecnología y Salud Pública
K1 SHIGELLA-FLEXNERI
K1 PROTEASE
K1 GENOME
K1 DEFINITIONS
K1 SEVERITY
K1 IMPACT
K1 GENES
AB BackgroundOne third of patients with Escherichia coli bacteraemia develop a dysregulated inflammatory response (sepsis/septic shock). Our objective was to investigate whether specific microbiological determinants of E. coli are associated to presentation with sepsis/shock.MethodsA matched case-control study was performed; 101 case-patients with E. coli bacteraemia presenting with sepsis (SEPSIS-3 criteria) and 101 control-patients with E. coli bacteraemia without sepsis were matched by service, sex, age, Charlson index, acquisition and source of the bacteraemia and empirical treatment. Whole genome sequencing of E. coli isolates was performed (Illumina MiSeq Inc.). Sequence type, serotype, fimH type, virulence factors, antibiotic resistance genes, plasmid replicons pathogenicity islands and prophages were determined. A multivariate model was built for presentation with sepsis/septic shock using conditional logistic regression. The predictive capacity on the observed data was measured with the area under the ROC curve (AUROC) with 95% confidence intervals (CI).ResultsHere we show that in the multivariate model (adjusted OR; 95% CI), the ST69 clone (7.53; 1.06-35.05) and pic gene (4.38; 1.53-12.54) are associated to presentation with sepsis/shock, while the genes papC (0.30; 0.12-0.74) and fdeC (0.18; 0.03-1.32) show a protective effect. The AUROC of this model is 0.81 (95% CI 0.74-0.87).ConclusionsWe identify E. coli bacterial factors associated with severe clinical presentation in patients with bacteraemia. Further studies would be needed to consider these factors as potential preventive or therapeutic targets.
PB SPRINGERNATURE
SN 2730-664X
YR 2026
FD 2026
LK http://hdl.handle.net/10498/40517
UL http://hdl.handle.net/10498/40517
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026