TY  - GEN 
AU  - Blandino-Rosano, Manuel
AU  - Barbaresso, Rebecca
AU  - Jiménez Palomares, Margarita
AU  - Bozadjieva, Nadejda
AU  - Werneck-de-Castro, Joao Pedro
AU  - Hatanaka, Masayuki
AU  - Mirmira, Raghavendra
AU  - Sonenberg, Nahum
AU  - Liu, Ming
AU  - Ruegg, Markus A.
AU  - Hall, Michael N.
AU  - Bernal-Mizrachi, Ernesto
A4  - Biomedicina, Biotecnología y Salud Pública
PY  - 2017
SN  - 2041-1723
UR  - http://hdl.handle.net/10498/34812
AB  - Deregulation of mTOR complex 1 (mTORC1) signalling increases the risk for metabolic diseases, including type 2 diabetes. Here we show that beta-cell-specific loss of mTORC1 causes diabetes and beta-cell failure due to defects in proliferation,...
LA  - eng
KW  - TRANSGENIC MICE
KW  - IN-VIVO
KW  - AUTOPHAGY REGULATION
KW  - S6 KINASE
KW  - PROINSULIN
KW  - BETA CELL MASS
KW  - BETA CELL FUNCTION
KW  - PHOSPHORYLATION
KW  - DIABETES
KW  - RESISTANCE
TI  - Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
DO  - 10.1038/ncomms16014
ER  -