TY  - GEN 
AU  - Muela-Zarzuela, Inés
AU  - Suarez Rivero, Juan Miguel
AU  - Boy Ruiz, Daniel
AU  - López Pérez, Juan
AU  - Sotelo Montoro, Marta
AU  - Navarrete Alonso, Maria del Mar
AU  - Collado, Isidro G.
AU  - González Collado, Isidro
AU  - Botubol Ares, José Manuel
AU  - Sanz, Alberto
AU  - Cordero, Mario D.
A4  - Química Orgánica
PY  - 2024
SN  - 1474-9726
SN  - 1474-9718
UR  - http://hdl.handle.net/10498/35694
AB  - The role of the inflammasomes in aging and progeroid syndromes remain understud-ied. Recently, MCC950, a NLRP3 inhibitor, was used in Zmpste24−/− mice to amelio-rate the phenotypes. However, the safety of MCC950 was questioned due to livertoxicity...
LA  - eng
PB  - Wiley
KW  - Dapansutrile
KW  - Lonafarnib
KW  - NLRP3
KW  - progeria
TI  - The NLRP3 inhibitor Dapansutrile improves the therapeutic action of lonafarnib on progeroid mice
DO  - 10.1111/ACEL.14272
ER  -