Physiological Mechanisms Inherent to Diabetes Involved in the Development of Dementia: Alzheimer’s Disease

Thumbnail
Identificadores

URI: http://hdl.handle.net/10498/32421

DOI: 10.3390/neurolint15040079

ISSN: 2035-8377

ISSN: 2035-8385

Files
Statistics
Metrics and citations
 
Share
Export
EndNoteBibTexRIS
Metadata
Show full item record
Author/s
Mohamed Mohamed, Himan; García Morales, VictoriaAuthority UCA; Sánchez Lara, Encarnación María; González Acedo, Anabel; Pardo Moreno, Teresa; Tovar Gálvez, María Isabel; Melguizo-Rodríguez, Lucía; Ramos-Rodríguez, Juan José
Date
2023
Department
Biomedicina, Biotecnología y Salud Pública
Source
Neurology International - 2023, Vol. 15 n. 4, pp. 1253 - 1272
Abstract
Type 2 diabetes mellitus (T2D) is a metabolic disease reaching pandemic levels worldwide. In parallel, Alzheimer’s disease (AD) and vascular dementia (VaD) are the two leading causes of dementia in an increasingly long-living Western society. Numerous epidemiological studies support the role of T2D as a risk factor for the development of dementia. However, few basic science studies have focused on the possible mechanisms involved in this relationship. On the other hand, this review of the literature also aims to explore the relationship between T2D, AD and VaD. The data found show that there are several alterations in the central nervous system that may be promoting the development of T2D. In addition, there are some mechanisms by which T2D may contribute to the development of neurodegenerative diseases such as AD or VaD.
Subjects
Alzheimer’s disease; dementia; diabetes; insulin; neurodegeneration; neuroinflammation; neuron death; vascular dementia
Collections
Atribución 4.0 Internacional
This work is under a Creative Commons License Atribución 4.0 Internacional