SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells

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SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells

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Title: SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells
Author: G. Galindo, José L.; Macías, Mariola; González Molinillo, José María; Muñoz-Suano, Alba; Torres, Ascensión; Varela Montoya, Rosa; García-Cozar, Francisco; Macías Domínguez, Francisco Antonio
Departments: Química Orgánica
xmlui.dri2xhtml.METS-1.0.item-source: Bioorganic & Medicinal Chemistry 20 (2012) 6662–6668
Abstract: Bioactive natural products are a potential source of new pharmaceuticals since they offer new modes of action and more specific activities. The use of derivatization also enables the optimal structure for their biological activity to be determined. In this study several epoxycurcuphenol derivatives were synthesized. The substitution pattern on the aromatic and oxirane rings was varied along with that at the benzylic position and the length of the side chain was altered. These changes were made in order to gain a deeper understanding of the structural requirements for activity. The biological activities of these compounds were evaluated on the human leukemia cell line Jurkat using an antiproliferative assay. The activity results and structural requirements are discussed.
Subject: antiproliferative bioassay ; leukemia cells ; Sunflower ; Helianthus annuus ; Epoxycurcuphenol derivatives ; SAR studies.
Handle: http://hdl.handle.net/10498/20258
Date: 2012-09

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