Botrylactone: new interest in an old moleculedreview of its absolute configuration and related compounds
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Author/sPinedo Rivilla, Cristina; Moraga Galindo, Javier; Hernández Galán, Rosario; Durán Patrón, Rosa; González Collado, Isidro
SourceTetrahedron, 2011, vol. 67, pp. 417-420
The absolute configuration of botrylactone, a unique compound with an interesting polyketide lactone skeleton with two oxirane bridges previously isolated from Botrytis cinerea and described as a powerful antibiotic, has been reviewed on the basis of sign of the optical rotation, NOE experiments and NMR method. The isolation of 7-deoxybotrylactone and 5-hydroxy-7-(4-hydroxydec-2(3)-enoyl) botrylactone enables us to characterize an intriguing new family of compounds with this interesting polyketide skeleton. A common biosynthetic origin with botcinin derivatives is proposed.