Structural and biosynthetic studies on eremophilenols related to the phytoalexin capsidiol, produced by Botrytis cinerea

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URI: http://hdl.handle.net/10498/30244

DOI: 10.1016/j.phytochem.2018.06.010

ISSN: 0031-9422

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Author/s
Moraga, Javier; Suárez Cáceres, Ivonne RocíoAuthority UCA; Silva Lima, Gesiane de; Conti, Raphael; Pinedo Rivilla, CristinaAuthority UCA; Moraga Galindo, JavierAuthority UCA; Barúa, Javier E.; Oliveira, Ana Ligia de; Aleu Casatejada, JosefinaAuthority UCA; Durán Patrón, Rosa MaríaAuthority UCA; Macías Sánchez, Antonio JoséAuthority UCA; Hanson, J. R.; Tallarico Pupo, Monica; Hernández Galán, RosarioAuthority UCA; González Collado, IsidroAuthority UCA
Date
2018
Department
Biomedicina, Biotecnología y Salud Pública; Química Orgánica
Source
Phytochemistry, 2018, 154, 10-18.
Abstract
A thorough study of the fermentation broth of three strains of Botrytis cinerea which were grown on a modified Czapek-Dox medium supplemented with 5 ppm copper sulphate, yielded five undescribed metabolites. These metabolites possessed a sesquiterpenoid (+)-4-epi-eremophil-9-ene carbon skeleton which was enantiomeric to that of the phytoalexin, capsidiol. The isolation of these metabolites when the fungus was stressed, suggests that they may be potential effectors used by B. cinerea to circumvent plant chemical defences against phytopatho genic fungi. The biosynthesis of these compounds has been studied using 2 H and 13C labelled acetate
Subjects
Botrytis cinerea; Sclerotiniaceae; Biosynthesis; Cryptic metabolites; Eremophilenols
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