Plasticity-Induced Motor Recovery of Bilateral Intermittent Theta Burst Stimulation in Parkinson's Disease: A Randomized, Double-Blind, Sham-Controlled, Crossover Trial

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URI: http://hdl.handle.net/10498/38602

DOI: 10.1007/s40120-025-00865-0

ISSN: 2193-6536

ISSN: 2193-8253

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Author/s
Rashid Abdu Rahim López, RaúlAuthority UCA; Macías García, PalomaAuthority UCA; Cruz Gómez, Álvaro JavierAuthority UCA; Cano Cano, FátimaAuthority UCA; Sánchez Fernández, Francisco LuisAuthority UCA; Sarrias Arrabal, EstebanAuthority UCA; Marco Delgado, Ángel José delAuthority UCA; González Moraleda, Álvaro AntonioAuthority UCA; Lozano Soto, Elena MaríaAuthority UCA; Sanmartino, Florencia SoledadAuthority UCA; Espinosa Rosso, Raúl; González Rosa, Javier JesúsAuthority UCA
Date
2026
Department
Biomedicina, Biotecnología y Salud Pública
Source
Neurology and Therapy - 2026, Vol. 15 n.1 pp. 345-366
Abstract
Cortico-subcortical dysfunction from dopaminergic depletion is a hallmark of Parkinson's disease (PD). Modulating primary motor cortex (M1) excitability with intermittent theta burst stimulation (iTBS) may restore network integrity in PD by targeting neurobiological changes at excitatory, structural, and serological levels. This study aimed to demonstrate the clinical and neurobiological effects of bilateral M1 iTBS in patients with PD. Bilateral M1 iTBS may represent a valuable adjunctive therapeutic option for pharmacological treatment of motor symptoms in patients with PD by promoting structural brain changes and enhancing synaptic plasticity in intermediate disease stages.
Subjects
Intermittent theta burst stimulation; Neurodegeneration and neuroplasticity serum biomarkers; Parkinson’s disease; Structural brain imaging
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This work is under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 Internacional