Further Mulinane and Azorellane Diterpenoids Isolated from Mulinum crassifolium and Azorella compacta
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Author/sBórquez, Jorge; Ardiles, Alejandro; Loyola, Luis Alberto; Peña-Rodriguez, Luis Manuel; Molina-Salinas, Gloria María; Vallejos, Javier; González Collado, Isidro; J. Simirgiotis, Mario
SourceMolecules 2014, 19, 3898-3908
The new mulinane diterpenoids 1 and 2 were isolated from the EtOAc extract of Mulinum crassifolium, while the rearranged mulinane 5, which was isolated for the first time from a natural source, was isolated from Azorella compacta. Compounds 1–2 were prepared by semi-synthesis thorough acetylation of the diterpene 17-acetoxymulinic acid (3). A mechanism of reaction was proposed, while the structures of the new compounds were elucidated on the basis of comprehensive spectroscopic analysis and computational methods.