Safety Study of Transcranial Static Magnetic Field Stimulation (tSMS) of the Human Cortex

Identificadores

URI: http://hdl.handle.net/10498/30688

DOI: 10.1016/j.brs.2014.12.002

ISSN: 1935-861X

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Autor/es
Oliviero, A; Carrasco-López, MC; Campolo, M; Perez-Borrego, Y; Soto Leon, Vanesa; González Rosa, Javier JesúsAutoridad UCA; Higuero, AM; Strange, BA; Abad-Rodriguez, J; Foffani, G
Fecha
2015-05-01
Departamento/s
Psicología
Resumen
Background: Transcranial static magnetic field stimulation (tSMS) in humans reduces cortical excitability. Objective: The objective of this study was to determine if prolonged tSMS (2 h) could be delivered safely in humans. Safety limits for this technique have not been described. Methods: tSMS was applied for 2 h with a cylindric magnet on the occiput of 17 healthy subjects. We assessed tSMS-related safety aspects at tissue level by measuring levels of neuron-specific enolase (NSE, a marker of neuronal damage) and S100 (a marker of glial reactivity and damage). We also included an evaluation of cognitive side effects by using a battery of visuomotor and cognitive tests. Results: tSMS did not induce any significant increase in NSE or S100. No cognitive alteration was detected. Conclusions: Our data indicate that the application of tSMS is safe in healthy human subjects, at least within these parameters.
Materias
NIBS; Neuron-specific enolase; Repetitive transcranial magnetic stimulation (rTMS); S100; Safety; Transcranial static magnetic field stimulation (tSMS)
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Esta obra está bajo una Licencia Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional